Seasonal variation in CSF5-HIAA concentrations in male rhesus macaques

Citation
Kb. Zajicek et al., Seasonal variation in CSF5-HIAA concentrations in male rhesus macaques, NEUROPSYCH, 22(3), 2000, pp. 240-250
Citations number
50
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROPSYCHOPHARMACOLOGY
ISSN journal
0893133X → ACNP
Volume
22
Issue
3
Year of publication
2000
Pages
240 - 250
Database
ISI
SICI code
0893-133X(200003)22:3<240:SVICCI>2.0.ZU;2-V
Abstract
Seasonal changes in cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5 -HIAA) concentrations were assessed on multiple occasions in 103 free-rangi ng male rhesus macaques (macaca mulatta). At the time of sampling subjects ranged between the ages of 2 and 6 years. CSF samples were collected betwee n the hours of 0900 and 1600 through the Fall, Winter, and Spring from 1990 through 1994. Data were analyzed in a general linear mixed model with rand om intercepts. Results indicated that CSF 5-HIAA concentrations decreased w ith age. CSF 5-HIAA concentrations were significantly increased in the Fall (October and November), which is the height of the breeding season, with n o evidence of differences between Winter and Spring. There was also some ev idence that the seasonal variation in CSF 5-HIAA concentrations was blunted in younger, more immature subjects. [Neuropsychopharmacology 22:240-250, 2 000] Published by Elsevier Science Inc.