A compilation of cellular transcription factor interactions with the HIV-1LTR promoter

The human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) represents a model promoter system and the identification and characterisat ion of cellular proteins that interact with this region has provided a basi c understanding about both general eukaryotic and HIV-1 proviral transcript ional regulation. To date a large number of sequence-specific DNA-protein i nteractions have been described for the HIV-1 LTR. The aim of this report i s to provide a comprehensive, updated listing of these HIV-1 LTR interactio ns, It is intended as a reference point to facilitate on-going studies char acterising the identity of cellular proteins interacting with the HIV-1 LTR and the functional role(s) of specific regions of the LTR for HIV-1 replic ation.