STUDIES IN MACROLIDE SYNTHESIS - STEREOCONTROLLED SYNTHESIS OF A C-1-C-13 SEGMENT OF CONCANAMYCIN-A

Authors
PATERSON I MCLEOD MD
Citation
I. Paterson et Md. Mcleod, STUDIES IN MACROLIDE SYNTHESIS - STEREOCONTROLLED SYNTHESIS OF A C-1-C-13 SEGMENT OF CONCANAMYCIN-A, Tetrahedron letters, 38(23), 1997, pp. 4183-4186
Citations number
37
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
23
Year of publication
1997
Pages
4183 - 4186
Database
ISI
SICI code
0040-4039(1997)38:23<4183:SIMS-S>2.0.ZU;2-2
Abstract
The C-1-C-13 segment 6 of concanamycin A (1) was prepared by a highly stereocontrolled route (87% overall ds) in 16 steps from the ester 9. Key steps are the one-pot aldol/reduction, 8 --> 12, and the HWE react ion, 18 + 19 --> 6. (C) 1997 Elsevier Science Ltd.