New efficient nickel- and palladium-catalyzed cross-coupling reactions mediated by tetrabutylammonium iodide

Authors
Piber, M Jensen, AE Rottlander, M Knochel, P
Citation
M. Piber et al., New efficient nickel- and palladium-catalyzed cross-coupling reactions mediated by tetrabutylammonium iodide, ORG LETT, 1(9), 1999, pp. 1323-1326
Citations number
27
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
9
Year of publication
1999
Pages
1323 - 1326
Database
ISI
SICI code
1523-7060(19991104)1:9<1323:NENAPC>2.0.ZU;2-O
Abstract
[GRAPHICS] The addition of Bu(4)Nl has been found to accelerate the palladium(0)-catal yzed cross-coupling between benzylic zinc bromides and aryl or alkenyl trif lates. Remarkably, it further allows a new nickel(0)-catalyzed cross-coupli ng between functionalized benzylic zinc reagents and primary alkyl iodides leading to polyfunctional products in good yields under mild reaction condi tions (0-20 degrees C, 4-16 h).