Enantioselective parallel synthesis using polymer-supported chiral co(salen) complexes

Authors
Peukert, S Jacobsen, EN
Citation
S. Peukert et En. Jacobsen, Enantioselective parallel synthesis using polymer-supported chiral co(salen) complexes, ORG LETT, 1(8), 1999, pp. 1245-1248
Citations number
15
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
8
Year of publication
1999
Pages
1245 - 1248
Database
ISI
SICI code
1523-7060(19991021)1:8<1245:EPSUPC>2.0.ZU;2-F
Abstract
[GRAPHICS] The kinetic resolution of epoxides with phenols catalyzed by a polymer supp orted Co(salen) complex is applied to the first enantioselective catalytic synthesis of parallel libraries, The corresponding 1-aryloxy-2-alcohols are obtained in high yield, purity, and enantiomeric excess. Further elaborati on with diversity elements provides highly efficient access to important cl asses of pharmacologically active compounds.