General and efficient catalytic amination of aryl chlorides using a palladium/bulky nucleophilic carbene system

Authors
Huang, J Grasa, G Nolan, SP
Citation
J. Huang et al., General and efficient catalytic amination of aryl chlorides using a palladium/bulky nucleophilic carbene system, ORG LETT, 1(8), 1999, pp. 1307-1309
Citations number
54
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
8
Year of publication
1999
Pages
1307 - 1309
Database
ISI
SICI code
1523-7060(19991021)1:8<1307:GAECAO>2.0.ZU;2-3
Abstract
[GRAPHICS] A combination of palladium and an imidazolium chloride has been used as cat alyst precursor in the amination of aryl chlorides. The imidazolium salt IP rHCl (4, IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) was found to provide the most efficient transformation rates in this catalytic system . This new system proves general and efficient for aryl chlorides as well a s aryl bromides and iodides.