Nonenzymatic kinetic resolution of 1,2-diols catalyzed by an organotin compound

Authors
Iwasaki, F Maki, T Nakashima, W Onomura, O Matsumura, Y
Citation
F. Iwasaki et al., Nonenzymatic kinetic resolution of 1,2-diols catalyzed by an organotin compound, ORG LETT, 1(7), 1999, pp. 969-972
Citations number
27
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
7
Year of publication
1999
Pages
969 - 972
Database
ISI
SICI code
1523-7060(19991007)1:7<969:NKRO1C>2.0.ZU;2-C
Abstract
[GRAPHICS] A new nonenzymatic kinetic resolution method of 1,2-diols 1 using chiral or ganotin catalyst A with benzoyl chloride was developed. A remarkable effect due to an inorganic base such as sodium carbonate and a small portion of w ater on the ee of the main products 2 was observed. The reaction showed hig h enantio- and chemoselectivities to 1,2-diols 1.