Fa. Davis et al., Asymmetric synthesis of alpha-methylphosphophenylalanine derivatives usingsulfinimine-derived enantiopure aziridine-2-phosphonates, ORG LETT, 1(7), 1999, pp. 1053-1055
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2-Methylaziridine-2-phosphonates were prepared from enantiopure sulfinimine
s and were demonstrated to be versatile synthetic intermediates for the syn
thesis of novel alpha-disubstituted and alpha,beta-trisubstituted alpha-ami
nophosphonate derivatives. The first asymmetric synthesis of both enantiome
rs of alpha-methylphosphophenylalanine is described.