Asymmetric synthesis of alpha-methylphosphophenylalanine derivatives usingsulfinimine-derived enantiopure aziridine-2-phosphonates

Authors
Davis, FA McCoull, W Titus, DD
Citation
Fa. Davis et al., Asymmetric synthesis of alpha-methylphosphophenylalanine derivatives usingsulfinimine-derived enantiopure aziridine-2-phosphonates, ORG LETT, 1(7), 1999, pp. 1053-1055
Citations number
23
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
7
Year of publication
1999
Pages
1053 - 1055
Database
ISI
SICI code
1523-7060(19991007)1:7<1053:ASOADU>2.0.ZU;2-K
Abstract
[GRAPHICS] 2-Methylaziridine-2-phosphonates were prepared from enantiopure sulfinimine s and were demonstrated to be versatile synthetic intermediates for the syn thesis of novel alpha-disubstituted and alpha,beta-trisubstituted alpha-ami nophosphonate derivatives. The first asymmetric synthesis of both enantiome rs of alpha-methylphosphophenylalanine is described.