Mechanistic studies on the repair of a novel DNA photolesion: The spore photoproduct

Authors
Mehl, RA Begley, TP
Citation
Ra. Mehl et Tp. Begley, Mechanistic studies on the repair of a novel DNA photolesion: The spore photoproduct, ORG LETT, 1(7), 1999, pp. 1065-1066
Citations number
9
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
7
Year of publication
1999
Pages
1065 - 1066
Database
ISI
SICI code
1523-7060(19991007)1:7<1065:MSOTRO>2.0.ZU;2-O
Abstract
[GRAPHICS] UV irradiation of spores results in the formation of the spore photoproduct . This novel DNA photolesion is repaired in the germinating spore in a reac tion catalyzed by the spare photoproduct lyase, Model studies, using a simp le bispyrimidine, suggest that this repair reaction proceeds by hydrogen ab straction from C6 of the spore photoproduct followed by beta-scission of th e bond linking the two pyrimidines and back hydrogen atom transfer.