Biosynthesis of isoprenoids in Escherichia coli: Stereochemistry of the reaction catalyzed by farnesyl diphosphate synthase

Authors
Leyes, AE Baker, JA Poulter, CD
Citation
Ae. Leyes et al., Biosynthesis of isoprenoids in Escherichia coli: Stereochemistry of the reaction catalyzed by farnesyl diphosphate synthase, ORG LETT, 1(7), 1999, pp. 1071-1073
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
7
Year of publication
1999
Pages
1071 - 1073
Database
ISI
SICI code
1523-7060(19991007)1:7<1071:BOIIEC>2.0.ZU;2-P
Abstract
[GRAPHICS] Farnesyl diphosphate (FPP) synthase from Escherichia coli catalyzes the con densation of isopentenyl diphosphate (IPP) and geranyl diphosphate (GPP) wi th selective removal of the pro-R hydrogen at C2 of IPP, the same stereoche mistry observed for the pig liver, yeast, and avian enzymes.