A chiral rhodium complex for rapid asymmetric transfer hydrogenation of imines with high enantioselectivity

Authors
Mao, JM Baker, DC
Citation
Jm. Mao et Dc. Baker, A chiral rhodium complex for rapid asymmetric transfer hydrogenation of imines with high enantioselectivity, ORG LETT, 1(6), 1999, pp. 841-843
Citations number
36
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
6
Year of publication
1999
Pages
841 - 843
Database
ISI
SICI code
1523-7060(19990923)1:6<841:ACRCFR>2.0.ZU;2-Y
Abstract
[GRAPHICS] A chiral rhodium complex, (R)-Cp*RhCl[(1S,2S)-p-TsNCH(C6H5)CH(C6H5)NH2] (1a , (S,S)-Cp*RhCITsDPEN), generated from [Cp*RhCl2](2) and (1S,2S) N-p-toluen esulfonyl-1,2-diphenylethylenediamine [(S,S) TsDPEN], and its enantiomer 1b were found to provide superior catalysts for the rapid, high yielding, asy mmetric transfer hydrogenation of some heterocyclic imines, using an HCO2H- Et3N azeotrope as the hydrogen source.