A general route to 4-imidazolyl-containing multidentate ligands for biomimetic studies

Authors
Collman, JP Zhong, M Wang, Z
Citation
Jp. Collman et al., A general route to 4-imidazolyl-containing multidentate ligands for biomimetic studies, ORG LETT, 1(6), 1999, pp. 949-951
Citations number
40
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
6
Year of publication
1999
Pages
949 - 951
Database
ISI
SICI code
1523-7060(19990923)1:6<949:AGRT4M>2.0.ZU;2-P
Abstract
[GRAPHICS] 4-Iodo-1-tritylimidazole undergoes magnesium-iodine exchange with a Grignar d reagent to give selectively the 4-magnesioimidazole derivative, which rea cts with esters to form a variety of poly-4-imidazolyl carbinol compounds i n 40-79% yields. A wide range of bi-, tri-, and pentadentate ligands featur ing 4-substituted imidazole units have been efficiently synthesized.