Highly regio- and stereoselective intramolecular 1,3-dipolar cycloadditions of norbornadiene-tethered nitrile oxides

Authors
Yip, C Handerson, S Jordan, R Tam, W
Citation
C. Yip et al., Highly regio- and stereoselective intramolecular 1,3-dipolar cycloadditions of norbornadiene-tethered nitrile oxides, ORG LETT, 1(5), 1999, pp. 791-794
Citations number
23
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
5
Year of publication
1999
Pages
791 - 794
Database
ISI
SICI code
1523-7060(19990909)1:5<791:HRASI1>2.0.ZU;2-D
Abstract
[GRAPHICS] Intramolecular cycloadditions with high regio and stereocontrol are importa nt methods for the efficient assembly of complex molecular structures. Effi cient routes to the synthesis of norbornadiene tethered nitrile oxides have been developed, and their intramolecular 1,3-dipolar cycloadditions were s tudied. The cycloadditions occurred in good yields for a variety of substra tes and were found to be highly regio and stereoselective.