Solid-phase enzymatic synthesis of oligonucleotides

Authors
Schmitz, C Reetz, MT
Citation
C. Schmitz et Mt. Reetz, Solid-phase enzymatic synthesis of oligonucleotides, ORG LETT, 1(11), 1999, pp. 1729-1731
Citations number
41
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
11
Year of publication
1999
Pages
1729 - 1731
Database
ISI
SICI code
1523-7060(199912)1:11<1729:SESOO>2.0.ZU;2-W
Abstract
[GRAPHICS] The controlled and selective synthesis of oligonucleotides on the solid pha se is possible:under mild aqueous conditions using the enzyme T4 RNA ligase , the resins being tentagel or kieselguhr/polydimethylacrylamide.