Synthesis of a C-linked antifreeze glycoprotein (AFGP) mimic: Probes for investigating the mechanism of action

Authors
Ben, RN Eniade, AA Hauer, L
Citation
Rn. Ben et al., Synthesis of a C-linked antifreeze glycoprotein (AFGP) mimic: Probes for investigating the mechanism of action, ORG LETT, 1(11), 1999, pp. 1759-1762
Citations number
63
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
11
Year of publication
1999
Pages
1759 - 1762
Database
ISI
SICI code
1523-7060(199912)1:11<1759:SOACAG>2.0.ZU;2-Z
Abstract
[GRAPHICS] A general convergent synthesis has been developed to afford a low molecular weight C-linked antifreeze glycoprotein (AFGP) mimic (9). Structural mimic s of AFGPs have tremendous potential as probes to better understand how nat ive AFGPs inhibit ice crystal growth in organisms that inhabit subzero envi ronments.