Aminoethylprolyl peptide nucleic acids (aepPNA): Chiral PNA analogues thatform highly stable DNA : aepPNA(2) triplexes

Authors
D'Costa, M Kumar, VA Ganesh, KN
Citation
M. D'Costa et al., Aminoethylprolyl peptide nucleic acids (aepPNA): Chiral PNA analogues thatform highly stable DNA : aepPNA(2) triplexes, ORG LETT, 1(10), 1999, pp. 1513-1516
Citations number
21
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
10
Year of publication
1999
Pages
1513 - 1516
Database
ISI
SICI code
1523-7060(19991118)1:10<1513:APNA(C>2.0.ZU;2-5
Abstract
[GRAPHICS] The replacement of the glycyl component in the peptide nucleic acid (PNA) b ackbone by a prolyl unit bearing a nucleobase leads to the aminoethylprolyl (aep) PNAs, which are chiral and cationic. The homooligomeric aepPNA binds to complementary DNA sequences with high affinity and sequence specificity , forming highly stable triplexes.