USE OF YOHIMBINE TO REVERSE PROLONGED EFFECTS OF XYLAZINE HYDROCHLORIDE IN A HORSE BEING TREATED WITH CHLORAMPHENICOL

Authors
GRUBB TL MUIR WW BERTONE AL BELUCHE LA GARCIACALDERON M
Citation
Tl. Grubb et al., USE OF YOHIMBINE TO REVERSE PROLONGED EFFECTS OF XYLAZINE HYDROCHLORIDE IN A HORSE BEING TREATED WITH CHLORAMPHENICOL, Journal of the American Veterinary Medical Association, 210(12), 1997, pp. 1771
Citations number
19
Categorie Soggetti
Veterinary Sciences
Journal title
Journal of the American Veterinary Medical Association → ACNP
ISSN journal
00031488
Volume
210
Issue
12
Year of publication
1997
Database
ISI
SICI code
0003-1488(1997)210:12<1771:UOYTRP>2.0.ZU;2-9
Abstract
Chloramphenicol can prolong effects of drugs that are metabolized by c ytochrome P-450 mixed-function oxidase enzymes. Concurrent use of xyla zine hydrochloride and chloramphenicol can result in xylazine-induced prolonged sedation and gastrointestinal stasis. Antagonism of effects of xylazine with yohimbine can alleviate prolonged sedation and gastro intestinal stasis.