Sudden onset coma disclosing neurosarcoidosis

BACKGROUND: Central nervous system involvement is uncommon in sarcoidosis, particularly in cases discovered in circumstances described in our case. CASE REPORT: A 38-year-old man with a history of pulmonary sarcoidosis diag nosed in 1991 was treated by budesonide. The clinical course was generally favorable until 1995 when the patient complained of rapid onset headache wh ich suddenly progressed to coma. The patient died 26 days later. DISCUSSION: The course of the neurological manifestations was remarkable in this case of neurosarcoidosis. The anatomic localization was also unusual with 3 distinct loci outside the central nervous system.