A family of chromatin remodeling factors related to Williams syndrome transcription factor

Authors
Bochar, DA Savard, J Wang, WD Lafleur, DW Moore, P Cote, J Shiekhattar, R
Citation
Da. Bochar et al., A family of chromatin remodeling factors related to Williams syndrome transcription factor, P NAS US, 97(3), 2000, pp. 1038-1043
Citations number
45
Categorie Soggetti
Multidisciplinary
Journal title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN journal
00278424 → ACNP
Volume
97
Issue
3
Year of publication
2000
Pages
1038 - 1043
Database
ISI
SICI code
0027-8424(20000201)97:3<1038:AFOCRF>2.0.ZU;2-K
Abstract
Chromatin remodeling complexes have been implicated in the disruption or re formation of nucleosomal arrays resulting in modulation of transcription, D NA replication, and DNA repair. Here we report the isolation of WCRF, a new chromatin-remodeling complex from HeLa cells. WCRF is composed of two subu nits, WCRF135, the human homolog of Drosophila ISWI, and WCRF180, a protein related to the Williams syndrome transcription factor. WCRF180 is a member of a family of proteins sharing a putative heterochromatin localization do main, a PHD finger, and a bromodomain, prevalent in factors involved in reg ulation of chromatin structure.