THE CHROMIUM REFORMATSKY REACTION - ACCESS TO ADJACENT QUARTERNARY CENTERS

Authors
WESSJOHANN L WILD H
Citation
L. Wessjohann et H. Wild, THE CHROMIUM REFORMATSKY REACTION - ACCESS TO ADJACENT QUARTERNARY CENTERS, Synthesis, (5), 1997, pp. 512
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
5
Year of publication
1997
Database
ISI
SICI code
0039-7881(1997):5<512:TCRR-A>2.0.ZU;2-2
Abstract
alpha-Bromo ketones, -esters and -nitriles react with chromium dichlor ide and ketones in a Barbier-type reaction to yield the kinetic crosse d aldol products with one or two new quarternary centers. The reaction does not require special activation of the reagent, proceeds at room temperature and is suitable for microscale preparations. Crotonates re act highly regioselectively to yield alpha-products. The influence of solvents is discussed.