Ednit influence on oxidation resistance of LDLP in hypertensive subjects

Aim. Evaluation of resistance of low density lipoproteins (LDLP) of the ser um to oxidation in patients with essential hypertension (EH) before and aft er course treatment with ednit. Materials and methods. 10 patients with mild or moderate EH aged 38-55 year s were given ednit for 1 or 2 months. 10 healthy males aged 35-48 years sew ed control. Results. EH patients had high baseline levels of lipid peroxidation product s in LDLP, while antioxidant resistance of LDPL was diminished by 67% (p < 0.05) compared to controls. Ednit treatment for 1 and 2 months enhanced thi s resistance in mild and moderate EH (p < 0.05). Conclusion. Ednit mises resistance of LDLP to oxidation and as A CE inhibit or lowers arterial pressure. Therefore it can be used in EH.