Functional heterogeneity of population of polymorphonuclear leukocytes in peripheral blood of patients with acute dysentery

Aim. To study chemiluminescence (CL) of polymorphonuclear neutrophils (PMNL ) in peripheral blood of patients with acute mild and moderate dysentery ca used by Shig. Flexneri in response to Re- and S-chemotype lipopolysaccharid e (LPS) Sh. Flexneri and agonists fMLP, PMA and OZ. Results. PMNL population proved functionally heterogeneic, correlating with acute dysentery severity. Subgroups of PMNL varied by CL amplitude, reserv e ability to additional stimulation. LPS rather modulated CL of PMNL than s timulated it. CL intensity depended on LPS structure and concentration. Mil d acute dysentery was characterized by pool of primed PMNL which had higher functional reserves. Conclusion. CL analysis can be used for raising accuracy of dysentery progn osis and severity, assessment of implications of functional state of neutro phil granulocytes for support of antiendotoxin immunity in acute dysentery.