Clinicomicrobiological assessment of therapeutic activity of antifungal drugs in patients with atopic dermatitis sensitized to yeast fungi

Aim. The study of therapeutic activity of local (natamycine) and systemic ( fluconasol) antifungal drugs in patients with atopic dermatitis (AD) with m ycogenic sensitization and candida carriage. Materials and methods. 29 patients with severe AD and diagnosed contaminati on of the skin lesions with yeast fungi have received antifungal treatment with fungicidal drugs in low-dose long-term course. Results. The drugs were effective in 83% of patients: poor effect was in 28 %, moderate - in 21% and good - in 34% of cases. 5(17%) patients did not re spond. Mild, moderate and severe AD responded in 87, 36 and 60% of patients , respectively. The highest response was registered in patients without sen sitization to yeast fungi (78%) or low sensitization (83%). In high sensiti zation the effect occurred in 57% of the cases. Conclusion. The authors have developed indications for treatment with antif ungal drugs in AD patients with mycogenic sensitization.