Antihypertensive efficacy, tolerance and safety of lisinopril (sinopril) and captopril (capoten) in patients with mild and moderate arterial hypertension

Aim. To compare effectiveness, tolerance and safety of two inhibitors of an giotensin-converting enzyme-sinopril (lisinopril) and capoten (captopril) - in outpatient treatment of patients with mild and moderate hypertension. Materials and methods. The patients were randomly assigned to sinopril or c apoten groups. Sinopril was given in daily dose 10-40 mg, capoten - in dail y dose 25-100 mg for 8 weeks. In insufficient antihypertensive effect of mo notherapy on day 21, hydrochlortiaside was added. The effect was judged by influence on arterial pressure, heart rate, tolerance (questionnaire), safe ty (blood count, urinalysis, ECG). Results. Sinopril produced good antihypertensive effect in 73.3% of patient s (monotherapy) and 88.9% (combined therapy). For capoten it was 68.9 and 8 2.2%, respectively. The time of the beginning of the antihypertensive effec t (4-20 days after the start of the treatment) for sinopril and capoten dif fered insignificantly and depended on hypertension severity (mild or modera te). Tolerance of both drugs was good, serious side effects were absent. Di scontinuation of the drugs was needed in 4% of patients, only. No negative action on bioelectric activity of the heart, clinical and biochemical blood indices were found. Conclusion. Sinopril and capoten demonstrate high antihypertensive activity .