A stereoselective synthesis of alpha-(1-hydroxyalkyl)-beta-substituted acrylic acid esters

Authors
Ben Ayed, T Villieras, J Amri, H
Citation
T. Ben Ayed et al., A stereoselective synthesis of alpha-(1-hydroxyalkyl)-beta-substituted acrylic acid esters, TETRAHEDRON, 56(5), 2000, pp. 805-809
Citations number
28
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
5
Year of publication
2000
Pages
805 - 809
Database
ISI
SICI code
0040-4020(20000128)56:5<805:ASSOAA>2.0.ZU;2-Z
Abstract
Nucleophilic substitution of vinylic iodide of methyl 2-(1-hydroxyalkyl)-3- iodo prop-2-enoates 8 in the presence of magnesium dialkyl cuprates generat ed in situ provided a stereoselective methodology for the synthesis of infr equent beta-substituted Baylis-Hillman products. (C) 2000 Elsevier Science Ltd. All rights reserved.