Steric effects in the enantioselective transfer hydrogenation of 2-aroylacetates

Authors
Everaere, K Carpentier, JF Mortreux, A Bulliard, M
Citation
K. Everaere et al., Steric effects in the enantioselective transfer hydrogenation of 2-aroylacetates, TETRAHEDR-A, 10(24), 1999, pp. 4663-4666
Citations number
9
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
24
Year of publication
1999
Pages
4663 - 4666
Database
ISI
SICI code
0957-4166(199912)10:24<4663:SEITET>2.0.ZU;2-E
Abstract
Benzoylacetate esters and aryl-substituted derivatives are efficiently redu ced in 2-propanol using the readily available catalytic combination (1S,2R) -ephedrine/[RuCl2(eta(6)-p-cymene)](2) to give the corresponding alcohols i n high yields and enantioselectivities (up to 94% ee). (C) 2000 Elsevier Sc ience Ltd. All rights reserved.