Highly stereocontrolled boron-mediated synthesis of beta-hydroxy-alpha-amino acids and dipeptides. Part 2

Authors
Di Felice, P Maestri, M Paradisi, F Porzi, G Sandri, S
Citation
P. Di Felice et al., Highly stereocontrolled boron-mediated synthesis of beta-hydroxy-alpha-amino acids and dipeptides. Part 2, TETRAHEDR-A, 10(24), 1999, pp. 4709-4714
Citations number
6
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
24
Year of publication
1999
Pages
4709 - 4714
Database
ISI
SICI code
0957-4166(199912)10:24<4709:HSBSOB>2.0.ZU;2-B
Abstract
The chiral synthons 1(a-d) were submitted to boron-mediated asymmetric alde r condensation with acetaldehyde and benzaldehyde providing, in high diaste reomeric excess (>95%), R,R-configured aldols 2(a-f) which are useful inter mediates to enantiomerically pure beta-hydroxy-alpha-amino acids. (C) 2000 Elsevier Science Ltd. All rights reserved.