Identification of a novel HLA-Cw*07 variant (Cw*0714) in a German Caucasian family

We report herein the identification of a new HLA-Cw*07 allele in two member s of a German Caucasian family. This novel allele, designated as Cw*0714, d iffers from Cw*07011 and Cw*0706 by two nucleotide changes: one at codon 66 (AAC-->AAG) in the exon 2, leading to an amino acid change from Asn to Lys ; and another silent substitution at codon 99 (TAT-->TAC) in the exon 3. Th e latest substitution (T-->C at the third position of codon 99) was not see n in any of the HLA-Cw*07 alleles reported so far, thus being characteristi c to the new HLA-Cw*0714 allele.