The ADAM gene family - surface proteins with adhesion and protease activity

Authors
Primakoff, P Myles, DG
Citation
P. Primakoff et Dg. Myles, The ADAM gene family - surface proteins with adhesion and protease activity, TRENDS GEN, 16(2), 2000, pp. 83-87
Citations number
47
Categorie Soggetti
Molecular Biology & Genetics
Journal title
TRENDS IN GENETICS
ISSN journal
01689525 → ACNP
Volume
16
Issue
2
Year of publication
2000
Pages
83 - 87
Database
ISI
SICI code
0168-9525(200002)16:2<83:TAGF-S>2.0.ZU;2-S
Abstract
An ADAM is a transmembrane protein that contains a disintegrin and metallop rotease domain and, therefore, it potentially has both cell adhesion and pr otease activities. Currently, the ADAM gene family has 29 members, although the function of most ADAM gene products is unknown. We discuss the ADAM ge ne products with known functions that act in a highly diverse set of biolog ical processes, including fertilization, neurogenesis, myogenesis, embryoni c TGF-alpha release and the inflammatory response.