Double-blind randomized comparison of single-dose ciprofloxacin versus intravenous cefazolin in patients undergoing outpatient endourologic surgery

Objectives. To compare the efficacy of single-dose oral ciprofloxacin with intravenous cefazolin as a prophylactic agent in patients undergoing outpat ient endourologic surgery. Methods. One hundred patients were enrolled in a double-blind, randomized s tudy to receive either ciprofloxacin (500 mg) or cefazolin (1 g) before sur gery. A postoperative clinical evaluation and urine cultures were performed 5 to 10 days after surgery. Patients undergoing ureteral stent insertion o r exchange, ureteroscopy, bladder biopsy, retrograde pyelography, collagen injection, and internal urethrotomy were included. Results. Postoperative urinary tract infection occurred in 7 (9.1%) of 77 p atients, including 3 (8.1%) of 57 and 4 (10.0%) of 40 of those who received ciprofloxacin and cefazolin, respectively (P = 0.77). There were no episod es of sepsis, and no patient with infection required hospitalization. The t otal cost associated with the administration of prophylactic antibiotics in the study population was $3657 less in those 50 patients who received cipr ofloxacin than in the 50 patients who received cefazolin. Conclusions. A single oral dose of ciprofloxacin in patients undergoing out patient endourologic surgery was equally effective as cefazolin in preventi ng postoperative urinary tract infection, but was associated with markedly lower overall costs. (C) 2000, Elsevier Science Inc.