Poorly differentiated carcinoma of the lung presenting with Lambert-Eaton myasthenic syndrome

Lambert-Eaton myasthenic syndrome commonly seen in small-cell lung cancer r epresents an autoimmune reaction against antigens coexpressed by tumor and neurons. It is rarely seen with other histologic subtypes. Symptoms antedat e the appearance of the neoplasm by weeks to years. Therapeutic options ran ge from immunosuppression, plasmapheresis, pharmacologic facilitation of ne uromuscular transmission, and definitive therapy of the primary tumor. This case report describes the rare association of Lambert-Eaton myasthenic syn drome with non-small-cell lung cancer.