PURPOSE: To report severe retinal vasculitis causing decreased vision in th
ree patients with the common variable immunodeficiency syndrome.
METHOD: Case report. Three patients with common variable immunodeficiency s
yndrome developed decreased vision secondary to retinal vasculitis, Fluores
cein angiography was performed in all three patients. Peribulbar injections
were given in one patient, and two patients were treated with oral steroid
s and cyclosporin.
RESULTS: All three patients were young and had classic common variable immu
nodeficiency syndrome. Bilateral retinal vasculitis and diffuse retinal ede
ma were present in all three patients, and two patients had retinal neovasc
ularization in the absence of ischemia. No evidence of intraocular infectio
n was present, and none was detected systematically. Visual acuity decrease
d in five of the six eyes and was responsive to treatment in only one patie
nt (both eyes).
CONCLUSION: Retinal vasculitis may be another autoimmune manifestation of c
ommon variable immunodeficiency syndrome. (Am J Ophthalmol 2000;129:269-270
. (C) 2000 by Elsevier Science Inc. All rights reserved.).