BINDING OF THE BOVINE CASEINOGLYCOPEPTIDE TO THE PLATELET MEMBRANE GLYCOPROTEIN GPIB-ALPHA

Authors
CHABANCE B QIAN ZY MIGLIORESAMOUR D JOLLES P FIAT AM
Citation
B. Chabance et al., BINDING OF THE BOVINE CASEINOGLYCOPEPTIDE TO THE PLATELET MEMBRANE GLYCOPROTEIN GPIB-ALPHA, Biochemistry and molecular biology international, 42(1), 1997, pp. 77-84
Citations number
19
Categorie Soggetti
Biology
Journal title
Biochemistry and molecular biology international → ACNP
ISSN journal
10399712
Volume
42
Issue
1
Year of publication
1997
Pages
77 - 84
Database
ISI
SICI code
1039-9712(1997)42:1<77:BOTBCT>2.0.ZU;2-7
Abstract
The bovine caseinoglycopeptide (residues 106-169), the C-terminal part of kappa-casein, inhibited the von Willebrand factor-dependent platel et aggregation in a dose-dependent manner. An affinity matrix made of the caseinoglycopeptide selectively bound the platelet membrane glycop rotein GPIb alpha which contains the von Willebrand factor binding sit e. The amino acid residues of GPIb alpha participating in the caseinog lycopepride binding were located after residue Glu(90).