MESQUITE GUM (PROSOPIS JULIFLORA) - POTENTIAL BINDER IN TABLET DOSAGEFORMS

Use of mesquite gum in tablet formulation by direct compression aad we t granulation method has been evaluated. Binding property of mesquite gum has been compared with the commercially used Acacia and Tragacanth gums. Tablets were prepared using 2 to 12 per cent increasing concent rations of mesquite gum. The effect of concentration on extent of bind ing has been evaluated by the parameters of weight variation, hardness , per cent friability and disintegration time of tablets prepared. Gra nule properties like particle size distribution, bulk density, per cen t compressibility, angle of repose etc, were studied. Suspensions were prepared in 2 to 20 per cent solution of mesquite gum and their stabi lity and sedimentation behaviour was studied to evaluate suspending pr operty.