Background: Hepatic artery infusion is the best choice of treatment for col
orectal liver. metastases, but it could be suggested for other hepatic tumo
rs or locally advanced pancreatic cancel: The need of a laparotomy for the
positioning of the arterial catheter has been the limiting factor for the d
iffusion of regional treatments. Materials and methods: 170 patients suffer
ing from primary or secondary liver tumours and pancreatic or bile ducts ca
ncer, underwent the positioning of intra-arterial hepatic port-a-cath by a
transcutaneous subclavian access in local anaesthesia. In 163 patients, a c
atheter was placed into the hepatic artery, 4 into the splenic and 3 into t
he gastroduodenal artery. Results: The procedure was performed successfully
in all patients. We observed 5 aneurysms of the subclavian artery and 9 th
rombosis of the hepatic artery. Only in 7 patients was arterial infusion su
spended for technical complications. We observed 10.6% of dislocation, but
dislodged catheters were always moved again into the hepatic artery. Conclu
sions: The development of percutaneous techniques of arterial port-a-cath i
mplantation could enlarge the indication of regional chemotherapy.