Morphology of the designed biodegradable cisplatin microsphere

We observed the morphological changes in microspheres containing cisplatin (CDDP) embedded in poly-dl,-l,lactic acid (PLA) and polyethylene glycol aci d (CDDP-PPMS). The in vitro release of CDDP from CDDP-PPMS continued for mo re than four weeks. Scanning electron microscopy revealed that though the p articles of CDDP-PPMS were spherical and superficially smooth, small pores with a superficial irregularity appeared six months Inter. CDDP-PPMS partic les were found in the stomata of the omentum after intraperitoneal administ ration. When CDDP-PPMS was administered after Yoshida sarcoma cells were in traperitoneally transplanted, CDDP-PPMS was observed histologically in the necrotic tissues of the omentum. These experimental results confirmed the r elease of CDDP from CDDP-PPMS and the histological efficacy of CDDP-PPMS in the omentum against peritoneal metastasis.