Effect of glutathione-modulating compounds on platinum compounds-induced cytotoxicity in human glioma cell lines

Authors
Iida, M Doi, H Asamoto, S Sugiyama, H Sakagami, H Kuribayashi, N Takeda, M Okamura, Y Matsumoto, K
Citation
M. Iida et al., Effect of glutathione-modulating compounds on platinum compounds-induced cytotoxicity in human glioma cell lines, ANTICANC R, 19(6B), 1999, pp. 5383-5384
Citations number
9
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
ANTICANCER RESEARCH
ISSN journal
02507005 → ACNP
Volume
19
Issue
6B
Year of publication
1999
Pages
5383 - 5384
Database
ISI
SICI code
0250-7005(199911/12)19:6B<5383:EOGCOP>2.0.ZU;2-5
Abstract
The relation between the effect of glutathione(GSH)modulating compounds and platinum compounds (Cisplatin, Nedaplatin)-induced cytotoxicity was invest igated Pretreatment human glioblastoma (T98G, U87MG) and glioma (KG1C) cell lines with L-buthionine-[S,R]-sulfoximine, which decrease the intracellula r GSH concentration, remarkably increased their sensitivity against platinu m compounds, whereas pretreatment with N-acetyl-L-cysteine, which increase the intracellular GSH concentration, only marginally protected the cells fr om the cytotoxic effect of platinum compounds. The results suggest that pla tinum compounds-induced cytotoxicity can be modified by GSH-modulating comp ounds in glioblastoma and glioma cell lines.