Tumor histopathology following new sensitizers: Dithiaporphyrin- and sulfoxaporphyrin-mediated photodynamic therapy

Background Our main aim was to evaluate tumor histopathology following new sensitizer-mediated photodynamic therapy (PDT). Materials and methods. In o rder to complete our studies we decided to rise photosensitizers, ie dithia porphyrin (DTP) and sulfoxaporphyrin (OXA) in combination with halogen lamp irradiation of presensitized tumors. The doses of sensitizers were: 2.5, 5 .0, 7.5 and 10.0 mg/kg of body weight and total light doses were: 50, 100 a nd 150 J/sq.cm at the selected wavelength. Following such a treatment we ha ve evaluated tumor necrosis of BFS1 fibrosarcoma growing on BALB/c mice. To gether with tumor necrosis evaluation we have examined skirt response to ph otodynamic treatment. Results. We have found that both new sensitizers caus ed significant tumor damage at no skin alterations. The induction of tumor. necrosis; seemed to be dose dependent, ie higher photodynamic doses (sensi tizer dose x light dose) resulted in more severe damage to the tumors than the lower doses. Conclusion. Our study showed that BFS1 fibrosarcoma is hig hly sensitive to PDT after application of new sensitizers. Both compounds c an be considered as potent tumor photosensitizers in future clinical trials .