A patient who was in remission with papillary thyroid cancer was inves
tigated for recently increasing thyroglobulin levels, I-123 diagnostic
whole-body imaging showed a focus of faint uptake centrally in the th
yroid bed, whereas an F-18 FDG PET whole-body scan showed two foci in
the right side of the neck, most likely in the cervical lymph nodes, a
nd was essentially negative in the thyroid bed. An I-131 postablation
scan confirmed all three neck foci, and showed an incidental pericardi
al effusion. F-18 FDG PET imaging might be helpful in thyroid cancer p
atients with elevated thyroglobulin levels and equivocal radioiodine s
cans and may help differentiate residual tumor from a thyroid remnant.