Although laryngotracheoesophageal clefts are often found in association wit
h other well-described anomalies, we know of no previous reported associati
on with eosinophilic gastroenteritis, a disorder of unknown etiology charac
terized by eosinophilic infiltration of the gastrointestinal tract. We trea
ted 2 children who had laryngeal clefts and eosinophilic gastroenteritis. S
ince the esophageal inflammatory changes found in eosinophilic gastroenteri
tis may persist despite aggressive therapy, management of the laryngo trach
eoesophageal clefts is more complicated. The diagnosis of eosinophilic gast
roenteritis should not be overlooked in patients with laryngotracheoesophag
eal clefts and warrants prompt referral to a pediatric gastroenterologist.