Clastogenicity of quinoline derivatives tested by micronucleus induction in vivo in the hepatocytes of partially hepatectomized mice

The induction of micronucleated liver cells (MN-liver cell) was examined wi th halogenated and hydroxylated quinolines using partially hepatectomized m ice. Among the chloroquinolines, 8-chloroquinoline demonstrated a significa ntly higher level of induction than the control. All the fluorinated deriva tives examined, except for 6-fluoroquinoline, induced significantly higher Levels, and there were no appreciable differences in MN-liver cell inductio n among the fluorinated quinolines, regardless of their mutagenic potencies in the Ames test. Of the hydroxylated quinolines examined, 2- and 4-isomer s, which are not mutagenic, induced MN-liver cells to the same extent as a mutagenic isomer, 8-hydroxyquinoline. It seems that clastogenicity was not satisfactorily correlated with mutagenicity in the Ames test as far as this class of compounds is concerned.