Influence of methionine and zinc on liver collagen in molybdenotic rats - Relationship with lipid peroxidation

Protective effects of methionine and zinc on collagenesis in the liver of m olybdenotic rats have been studied during present investigations. Further, the relationship between two important pathobiological phenomena (viz. lipi d peroxidation and collagenesis) has also been examined. Biological observa tions suggest that cotreatment with methionine only improves the growth of molybdenotic rats; however, the hepatosomatic index improved in rats supple mented with both methionine and zinc. Administration of methionine and zinc to molybdenum-fed rats decreased liver collagen. Results on urinary hydrox yproline support these observations. Lipid peroxidation was also inhibited in the liver of protected rats. We suggest that collagenesis can be control led by inhibiting the generation of reactive oxygen species. An improvement in liver function in rats protected with methionine and zinc has also been suggested.