Citation
K. Iwamoto et al., Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by fungi, BIOS BIOT B, 64(1), 2000, pp. 194-197
Citations number
17
Categorie Soggetti
Agricultural Chemistry","Biochemistry & Biophysics
Journal title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN journal
09168451
→ ACNP
Volume
64
Issue
1
Year of publication
2000
Pages
194 - 197
Database
ISI
SICI code
0916-8451(200001)64:1<194:AROE23>2.0.ZU;2-6
Abstract
Seven fungi, which are found to reduce ethyl 3-oxobutanoate in high yields,
were tested for their reducing ability for ethyl 2-methyl 3-oxobutanoate.
We obtained some interesting findings. In particular, Penicillium purpuroge
num reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols wit
h the diastereomer (anti/syn) ratio of 93/7 with the enantiomeric excess of
anti-(2S,3S)- and syn-(2S,3R)-hydroxy esters of 90 and >99 ee%, respective
ly.