Human midbrain dopamine neurons express serotonin 2A receptor: an immunohistochemical demonstration

Authors
Ikemoto, K Nishimura, A Okado, N Mikuni, M Nishi, K Nagatsu, I
Citation
K. Ikemoto et al., Human midbrain dopamine neurons express serotonin 2A receptor: an immunohistochemical demonstration, BRAIN RES, 853(2), 2000, pp. 377-380
Citations number
19
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
853
Issue
2
Year of publication
2000
Pages
377 - 380
Database
ISI
SICI code
0006-8993(20000124)853:2<377:HMDNES>2.0.ZU;2-2
Abstract
We demonstrated intense serotonin (5-HT) 2A receptor immunoreactivity in th e human ventral tegmental area (VTA) using by a recently raised antibody ag ainst 5-HT2A receptor. The substantia nigra (SN) neurons also showed 5-HT2A receptor immunoreactivity. Double immunohistochemistry of 5-HT2A receptor and tyrosine hydroxylase (TH) revealed many neurons doubly labeled by 5-HT2 A receptor and TH in the VTA and SN. It is suggested that activity of human midbrain dopaminergic neurons might be strongly regulated via 5-HT2A recep tors at the level of their originating nuclei. (C) 2000 Elsevier Science B. V. All rights reserved.