Genetic variation and covariation of parathyroid hormone levels and bone density in the human population

The present study was an attempt to evaluate the relative importance of fam ilial/genetic factors in interindividual variation of plasma concentrations of parathyroid hormone (PTH) and bone mineral density (BMD). We also exami ned to what extent common genetic and environmental factors may be involved in covariation between the hormone concentrations and BMD levels. Ninety-five nuclear pedigrees (consisting of 187 males and 168 females, age d 18-91 and 18-86 years old, respectively), from several small villages in the Chuvasha Autonomy, Russia, were assessed for PTH, sex hormones, and BMD . PTH plasma levels were measured in duplicate by immunoradiometric assay u sing an N-tact PTH SP kit. Standard roentgenography was done from the secon d and third phalanges of the middle finger on both hands for assessment of compact and cancellous bone BMD separately. The present study clearly confi rmed the results of the previous genetic analyses of BMD which indicated th at between 47% and 60% of the total variance of BMD, adjusted for sex and a ge effects, were attributable to genetic factors. Genetic factors also cont ributed significantly to interindividual variation of PTH. Constraining the se additive genetic effects to zero dramatically increased the likelihood r atio (P < 0.001), indicating that at least 30% of the hormone plasma variat ion was attributable to genetic sources. The results of bivariate decomposi tion analysis were not clear cut. Two types of bivariate analyses showed th at PTH-BMD genetic correlations according to sex and between the opposite s exes were consistently negative, but only marginally significant.