1. The fluid homeostasis of the brain depends both on the endothelial blood
-brain barrier and on the epithelial blood-cerebrospinal fluid (CSF) barrie
r located at the choroid plexuses and the outer arachnoid membrane.
2. The brain has two fluid environments: the brain interstitial fluid, whic
h surrounds the neurons and glia, and the CSF, which fills the ventricles a
nd external surfaces of the central nervous system.
3. CSF acts as a fluid cushion for the brain and as a drainage route for th
e waste products of cerebral metabolism.
4. Recent findings suggest that CSF may also act as a "third circulation" c
onveying substances secreted into the CSF rapidly to many brain regions.