Synthesis of J-111,347, a novel 1 beta-methylcarbapenem with broad-spectrum antibacterial activity

Authors
Imamura, H Ohtake, N Sakuraba, S Shimizu, A Yamada, K Morishima, H
Citation
H. Imamura et al., Synthesis of J-111,347, a novel 1 beta-methylcarbapenem with broad-spectrum antibacterial activity, CHEM PHARM, 48(2), 2000, pp. 310-311
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
48
Issue
2
Year of publication
2000
Pages
310 - 311
Database
ISI
SICI code
0009-2363(200002)48:2<310:SOJAN1>2.0.ZU;2-J
Abstract
Synthesis of J-111,347 (1),(1)) a new 1 beta-methylcarbapenem with broad-sp ectrum antibacterial activity including that against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, was achieved via d iastereoselective preparation of a side-chain thiol 3 from an optically act ive (R)-3.4-dihydroxybutanal 4.