[2.2]Paracyclophane-derived N-acylosazol-2(3H)-one as a suitable planar chiral auxiliary for the enantioselective synthesis of beta-hydroxy acids

Authors
Fringuelli, F Piermatti, O Pizzo, F Ruzziconi, R
Citation
F. Fringuelli et al., [2.2]Paracyclophane-derived N-acylosazol-2(3H)-one as a suitable planar chiral auxiliary for the enantioselective synthesis of beta-hydroxy acids, CHEM LETT, (1), 2000, pp. 38-39
Citations number
11
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
1
Year of publication
2000
Pages
38 - 39
Database
ISI
SICI code
0366-7022(20000105):1<38:[NAASP>2.0.ZU;2-#
Abstract
The synthesis of optically active (+)-(R)-[2.2]paracyclophano[4,5-d]-oxazol -2(3H)-one is described. The aldol reaction of N-acyl derivatives of this p lanar chiral auxiliary with beazaldehyde occurs with good diastereo- and en antioselectivity.