The control of T cell responses by dendritic cell subsets

Authors
Reid, SD Penna, G Adorini, L
Citation
Sd. Reid et al., The control of T cell responses by dendritic cell subsets, CURR OP IM, 12(1), 2000, pp. 114-121
Citations number
77
Categorie Soggetti
Immunology
Journal title
CURRENT OPINION IN IMMUNOLOGY
ISSN journal
09527915 → ACNP
Volume
12
Issue
1
Year of publication
2000
Pages
114 - 121
Database
ISI
SICI code
0952-7915(200002)12:1<114:TCOTCR>2.0.ZU;2-V
Abstract
Dendritic cells are known as the most efficient antigen-presenting cell typ e to activate naive T cells; however, they are able to do more than just ef ficiently present antigen to T cells. They are key modulators of the immune response that can influence Th cell differentiation by preferentially indu cing Th type 1 or 2 cell responses, and the differential polarisation of CD 4(+) T cells appears to be mediated by discrete dendritic cell subsets.