LY354740 affects startle responding but not sensorimotor gating or discriminative effects of phencyclidine

Authors
Schreiber, R Lowe, D Voerste, A De Vry, J
Citation
R. Schreiber et al., LY354740 affects startle responding but not sensorimotor gating or discriminative effects of phencyclidine, EUR J PHARM, 388(2), 2000, pp. R3-R4
Citations number
7
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
00142999 → ACNP
Volume
388
Issue
2
Year of publication
2000
Pages
R3 - R4
Database
ISI
SICI code
0014-2999(20000128)388:2<R3:LASRBN>2.0.ZU;2-2
Abstract
LY354740 {(1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate monoh ydrate}, a selective group II metabotropic glutamate (mGlu) receptor agonis t, was recently reported to attenuate the behavioral effects of phencyclidi ne (PCP) in rats. In the present study, LY354740 failed to attenuate the di scriminative stimulus properties of PCP and its disruption of prepulse inhi bition of the acoustic startle response, at a dose range which decreased st artle responding. The suggestion that mGlu group II receptor activation ind uces antipsychotic effects may be premature. (C) 2000 Elsevier Science B.V. All rights reserved.